Long-term treatment with THC has been found to have cognition enhancing and anti-ageing effects, according to new research.
Researchers from the University Hospital Bonn (UKB) and the University of Bonn together with a team from Hebrew University (Israel) have demonstrated in animal studies that a low-dose, long-term administration of cannabis may not only reverse ageing processes in the brain, but could also have an anti-ageing effect.
Their findings are published in the journal ACS Pharmacology & Translation Science.
The role of mTOR protein on metabolism and cognitive performance
According to the research team, the key to this is the protein switch mTOR [Mechanistic Target of Rapamycin], the central hub for cell growth and metabolism, which influences cognitive performance and metabolic processes in the body.
Information about the availability or scarcity of resources is crucial for the regulation of metabolism. The so-called metabolome is a complex reaction network that summarises all metabolic properties of a cell or tissue. As a sensitive intracellular energy sensor system, its activity has a major influence on ageing by regulating cell metabolism.
A reduction in mTOR activity through a low-calorie diet, intensive physical activity or pharmacological treatment therefore has a general anti-ageing effect.
But the ageing of the brain is also accompanied by a reduced ability to change neuronal connections, known as synaptic plasticity.
Reduced mTOR activity can also have a negative effect on the ageing brain by reducing the formation of new synapses on a nerve cell and therefore, also cognitive abilities.
“Anti-ageing strategies based on the reduction of mTOR activity might not only be ineffective but even counterproductive against brain ageing,” explains Professor Dr Andreas Zimmer, Director of the Institute of Molecular Psychiatry at the UKB and member of the Cluster of Excellence ImmunoSensation2 at the University of Bonn.
“In our current work, we have now found a strategy to solve this dilemma.”
Cannabis reverses the ageing process in the brain
In a previous study, the Bonn researchers, together with a team from the Hebrew University of Jerusalem, were able to show that long-term, low-dose administration of tetrahydrocannabinol (THC), the active ingredient in cannabis, has an anti-ageing effect on the brain by restoring cognitive abilities and synapse density in ageing mice.
But whether changes in mTOR signalling and the metabolome are linked to the positive effects on the ageing brain has remained an open question.
“We have now been able to show that treatment with THC has a tissue-dependent and dual effect on mTOR signalling and the metabolome,” says Dr Andras Bilkei-Gorzo from the Institute of Molecular Psychiatry at the UKB, who is also a researcher at the University of Bonn.
THC treatment in the brain led to a transient increase in mTOR activity and levels of intermediates involved in energy production and amino acids. This enabled an increased synthesis of synaptic proteins and the formation of new synapses.
The researchers found a similarly strong reduction in mTOR activity of mice in adipose tissue and in the content of amino acids and carbohydrate metabolites in blood plasma as after a low-calorie diet or after intensive physical activity.
“We concluded that long-term THC treatment initially has a cognition-enhancing effect by increasing energy and synaptic protein production in the brain, followed by an anti-aging effect by decreasing mTOR activity and metabolic processes in the periphery,” says Bilkei-Gorzo.
“Our study suggests that a dual effect on mTOR activity and the metabolome could be the basis for an effective anti-aging and cognition-enhancing drug.”
The post THC has anti-ageing and cognition enhancing effects, finds study appeared first on Cannabis Health News.
Go to Source
Author: News Editor
